Table II.
Genotype and allele frequencies of UVRAG SNPs in RA patients and control subjects.a
| RA | Control | 95% CI | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| SNP | Genotype/allele | Freq | % | Freq | % | Model | OR | LCL | UCL | P-value | PC |
| rs7111334 | C/C | 163 | 67.1 | 245 | 58.9 | Codominant 1 | 0.870 | 0.600 | 1.250 | 0.009 | 0.044 |
| C/T | 75 | 30.9 | 141 | 33.9 | Codominant 2 | 0.240 | 0.090 | 0.670 | |||
| T/T | 5 | 2.0 | 30 | 7.2 | Dominant | 0.760 | 0.530 | 1.070 | 0.120 | 0.600 | |
| Recessive | 0.250 | 0.090 | 0.700 | 0.003 | 0.015 | ||||||
| Over-dominant | 0.950 | 0.660 | 1.360 | 0.760 | 1.000 | ||||||
| Log-additive | 0.700 | 0.520 | 0.950 | 0.019 | 0.095 | ||||||
| C | 401 | 83.0 | 631 | 76.0 | |||||||
| T | 85 | 17.0 | 201 | 24.0 | 0.665 | 0.502 | 0.883 | 0.005 | 0.025 | ||
| rs7933235 | A/A | 130 | 53.7 | 241 | 58.1 | Codominant 1 | 1.460 | 1.020 | 2.090 | 0.038 | 0.190 |
| A/G | 98 | 40.5 | 140 | 33.7 | Codominant 2 | 0.690 | 0.340 | 1.390 | |||
| G/G | 14 | 5.8 | 34 | 8.2 | Dominant | 1.290 | 0.920 | 1.810 | 0.140 | 0.700 | |
| Recessive | 0.600 | 0.300 | 1.180 | 0.130 | 0.650 | ||||||
| Over-dominant | 1.520 | 1.070 | 2.160 | 0.020 | 0.100 | ||||||
| Log-additive | 1.080 | 0.820 | 1.400 | 0.600 | 1.000 | ||||||
| A | 358 | 74.0 | 622 | 75.0 | |||||||
| G | 126 | 26.0 | 208 | 25.0 | 1.052 | 0.814 | 1.360 | 0.696 | 1.000 | ||
| rs1380075 | T/T | 240 | 98.8 | 403 | 96.6 | Codominant 1 | 0.420 | 0.110 | 1.590 | 0.300 | 1.000 |
| T/A | 3 | 1.2 | 13 | 3.1 | Codominant 2 | 0.000 | 0.000 | NA | |||
| A/A | 0 | 0.0 | 1 | 0.2 | Dominant | 0.400 | 0.110 | 1.490 | 0.140 | 1.000 | |
| Recessive | 0.000 | 0.000 | NA | 0.470 | 1.000 | ||||||
| Over-dominant | 0.420 | 0.110 | 1.590 | 0.170 | 1.000 | ||||||
| Log-additive | 0.400 | 0.110 | 1.460 | 0.130 | 1.000 | ||||||
| T | 483 | 99.0 | 819 | 98.0 | |||||||
| A | 3 | 1.0 | 15 | 2.0 | 0.339 | 0.098 | 1.177 | 0.089 | 0.445 | ||
| rs1458836 | G/G | 131 | 55.7 | 227 | 57.9 | Codominant 1 | 1.270 | 0.880 | 1.840 | 0.200 | 1.000 |
| G/A | 90 | 38.3 | 134 | 34.2 | Codominant 2 | 0.700 | 0.340 | 1.440 | |||
| A/A | 14 | 6.0 | 31 | 7.9 | Dominant | 1.150 | 0.810 | 1.640 | 0.430 | 1.000 | |
| Recessive | 0.640 | 0.310 | 1.290 | 0.200 | 1.000 | ||||||
| Over-dominant | 1.320 | 0.920 | 1.900 | 0.140 | 0.700 | ||||||
| Log-additive | 1.020 | 0.770 | 1.340 | 0.920 | 1.000 | ||||||
| G | 352 | 75.0 | 588 | 75.0 | |||||||
| A | 118 | 25.0 | 196 | 25.0 | 1.006 | 0.772 | 1.309 | 0.966 | 1.000 | ||
| rs636420 | C/C | 121 | 51.3 | 208 | 50.0 | Codominant 1 | 1.020 | 0.710 | 1.460 | 0.990 | 1.000 |
| C/T | 96 | 40.7 | 171 | 41.1 | Codominant 2 | 1.030 | 0.540 | 1.960 | |||
| T/T | 37 | 8.9 | 19 | 8.9 | Dominant | 1.020 | 0.730 | 1.440 | 0.900 | 1.000 | |
| Recessive | 1.030 | 0.550 | 1.910 | 0.940 | 1.000 | ||||||
| Over-dominant | 1.010 | 0.720 | 1.430 | 0.940 | 1.000 | ||||||
| Log-additive | 1.020 | 0.780 | 1.330 | 0.900 | 1.000 | ||||||
| C | 338 | 72.0 | 587 | 71.0 | |||||||
| T | 134 | 28.0 | 245 | 29.0 | 0.950 | 0.740 | 1.219 | 0.686 | 1.000 | ||
a
The total numbers of genotypes and alleles in each SNP are different, due to the exclusion of unclear or missing genotype data. Bold print denotes statistical significance.
UVRAG, ultraviolet radiation resistance-associated gene; SNPs, single-nucleotide polymorphisms; RA, rheumatoid arthritis; CI, confidence interval; Freq, frequency; OR, odds ratio; LCL, lower confidence limit; UCL, upper confidence limit; Pc, P-value corrected by the Bonferroni method; NA, not available.