Representative polymerase chain reaction-restriction fragment length polymorphism analysis of the human homolog of the 8-oxoguanine DNA glycosylase 1 Ser326Cys polymorphism. Lane M, DNA marker; lanes 1, 3 and 5, the PCR product prior to digestion was a 200-bp band; lane 2, the Cys/Cys homozygote is cleaved by Fnu4HI and yields a 100-bp band; lane 4, the Ser/Ser homozygote is not cleaved by Fnu4HI and remains a single 200-bp band; lane 6, the Ser/Cys heterozygote contains the 200- and 100-bp bands following restriction digestion.