Table III.
Stratified analyses based on smoking and histology type of the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms (TT vs. CC/CT) and lung cancer.
| Cases
|
Controls
|
||||||
|---|---|---|---|---|---|---|---|
| Subgroup analyses | TT | CC/CT | TT | CC/CT | OR (95% CIs) | P-value | Refs. |
| Ever smoker | 104 | 498 | 72 | 661 | 1.38 (0.59–3.21) | 0.46 | (12,17) |
| Never smoker | 55 | 246 | 42 | 220 | 1.28 (0.78–2.10) | 0.33 | (12,17) |
| Squamous carcinoma | 103 | 131 | 137 | 392 | 1.53 (1.09–2.14) | 0.01 | (11,13,14) |
| Adenocarcinoma | 88 | 142 | 137 | 392 | 2.13 (0.90–5.00) | 0.08 | (11,13,14) |
OR, odds ratio; CI, confidence interval.