Table II.
Genotype distribution of CASP-1, -2 and -5 gene polymorphisms in case and control groups.
| First author (ref.) | SNP | Case
|
Control
|
HWE test
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | 1 | 2 | 1/1 | 1/2 | 2/2 | Total | 1 | 2 | 1/1 | 1/2 | 2/2 | χ2 | P-value | ||
| Ulybina et al (15) | rs4647297 (C>G) | 111 | 213 | 9 | 102 | 9 | 0 | 110 | 211 | 9 | 101 | 9 | 0 | 0.20 | 0.655 |
| rs507879 (A>G) | 111 | 119 | 103 | 29 | 61 | 21 | 110 | 112 | 108 | 34 | 44 | 32 | 4.39 | 0.036 | |
| rs523104 (G>C) | 647 | 772 | 522 | 240 | 292 | 115 | 833 | 1037 | 629 | 328 | 381 | 124 | 0.60 | 0.438 | |
| Hart et al (21) | rs501192 (G>A) | 436 | 706 | 166 | 286 | 134 | 16 | 435 | 705 | 165 | 282 | 141 | 12 | 1.29 | 0.255 |
| Mittal et al (14) | rs3181320 (G>C) | 200 | 234 | 166 | 75 | 84 | 41 | 225 | 285 | 165 | 96 | 93 | 36 | 2.73 | 0.099 |
| rs507879 (T>C) | 200 | 217 | 183 | 65 | 87 | 48 | 225 | 263 | 187 | 83 | 97 | 45 | 2.85 | 0.092 | |
| Mittal et al (22) | rs3181320 (G>C) | 192 | 219 | 165 | 66 | 87 | 39 | 225 | 285 | 165 | 96 | 93 | 36 | 2.73 | 0.099 |
| rs507879 (T>C) | 192 | 202 | 182 | 62 | 78 | 52 | 225 | 263 | 187 | 83 | 97 | 45 | 2.85 | 0.092 | |
SNP, single nucleotide polymorphism; 1, wild allele; 2, variant allele; 1/1, wild homozygote; 1/2, heterozygote; 2/2, variant homozygote; HWE, Hardy -Weinberg equilibrium.