Table III.
Meta-analysis of the association between polymorphisms of CASP-1, -2 and -5 genes and cancer susceptibility.
| Gene name | Gene/SNP | Case (n/N) | Control (n/N) | OR (95% CI) | P-value | Effect model |
|---|---|---|---|---|---|---|
| CASP-1 | ||||||
| rs501192 (G>A) | A allele | 166/872 | 165/870 | 1.00 (0.79–1.28) | 0.97 | Fixed |
| A carrier | 150/436 | 153/435 | 0.97 (0.73–1.28) | 0.81 | ||
| CASP-2 | ||||||
| rs4647297 (C>G) | G allele | 9/222 | 9/220 | 0.99 (0.39–2.54) | 0.98 | Fixed |
| G carrier | 9/111 | 9/110 | 0.99 (0.38–2.60) | 0.98 | ||
| CASP-5 | ||||||
| rs507879 (T>C) | C allele | 468/1006 | 482/1120 | 1.15 (0.97–1.36) | 0.12 | Fixed |
| C carrier | 347/503 | 360/560 | 1.23 (0.95–1.59) | 0.12 | ||
| rs3181320 (G>C) | C allele | 331/784 | 330/900 | 1.26 (1.04–1.54) | 0.02 | Fixed |
| C carrier | 251/392 | 258/450 | 1.33 (1.00–1.75) | 0.05 | ||
| rs523104 (G>C) | C allele | 522/1294 | 629/1666 | 1.11 (0.96–1.29) | 0.15 | Fixed |
| C carrier | 407/647 | 505/833 | 1.10 (0.89–1.36) | 0.37 |
SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.