Table 3.

MACC1 expression is an independent prognostic factor for HCC patients following LT.

	Cumulative recurrence		Overall survival
Variable	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Univariate analysis†
Age, year (≥50 versus <50)	0.546 (0.355-0.841)	0.006	0.808 (0.521-1.253)	0.341
Gender (male versus female)	2.161 (0.834-5.095)	0.117	2.654 (0.970-7.261)	0.057
Preoperative treatment (yes versus no)	1.196 (0.747-1.916)	0.457	1.025 (0.617-1.703)	0.924
Tumor size (>5 cm versus ≤5 cm)	3.934 (2.527-6.123)	< 0.001	3.070 (1.960-4.809)	< 0.001
Tumor number (multiple versus single)	2.595 (1.637-4.114)	< 0.001	2.356 (1.468-3.779)	< 0.001
Tumor differentiation (poor versus well+moderate)	1.485 (0.947-2.265)	0.066	1.043 (0.672-1.620)	0.851
Preoperative AFP, ng/ml (>400 versus ≤400)	2.261 (1.440-3.548)	< 0.001	1.820 (1.151-2.878)	0.010
Vascular invasion (yes versus none)	2.995 (1.959-4.580)	< 0.001	2.310 (1.491-3.579)	< 0.001
MACC1high versus MACC1low	2.193 (1.430-3.364)	< 0.001	2.127 (1.362-3.322)	0.001
METhigh versus METlow	1.460 (0.951-2.242)	0.084	1.369 (0.878-2.133)	0.166
FAKhigh versus FAKlow	1.858 (1.204-2.867)	0.005	1.613 (1.035-2.514)	0.035
Combination of MACC1 and FAK		< 0.001		< 0.001
II versus I	2.722 (1.399-5.296)	0.003	2.185 (1.088-4.387)	0.028
III versus I	3.602 (1.809-7.174)	< 0.001	3.001 (1.509-5.970)	0.002
IV versus I	3.478 (1.884-6.420)	< 0.001	2.904 (1.566-5.383)	0.001
Multivariate analysis†
Age, year (≥50 versus <50)	-	0.153	-	-
Tumor size (>5 cm versus ≤5 cm)	3.350 (2.123-5.288)	< 0.001	2.719 (1.725-4.286)	< 0.001
Tumor number (multiple versus single)	-	0.141	-	0.150
Preoperative AFP, ng/ml (>400 versus ≤400)	1.789 (1.130-2.833)	0.013	1.624 (1.020-2.587)	0.041
Vascular invasion (yes versus none)	2.267 (1.474-3.485)	< 0.001	1.853 (1.192-2.880)	0.006
MACC1high versus MACC1low	2.495 (1.616-3.851)	< 0.001	2.280 (1.453-3.580)	< 0.001
FAKhigh versus FAKlow	-	0.127	-	0.136
Combination of MACC1 and FAK	-	< 0.001	-	< 0.001
II versus I	2.518 (1.286-4.929)	0.007	2.116 (1.048-4.274)	0.037
III versus I	3.444 (1.707-6.948)	0.001	3.001 (1.509-5.970)	0.002
IV versus I	3.902 (2.078-7.328)	< 0.001	3.381 (1.809-6.316)	< 0.001

Abbreviations: MACC1, metastasis-associated in colon cancer-1; FAK, focal adhesion kinase; AFP, alpha-fetoprotein; 95% CI, 95% confidence interval.

†Statistical analyses were performed by Cox proportional hazards regression (univariate and multivariate analysis).

I, MACC1^low/FAK^low; II, MACC1^low/FAK^high; III, MACC1^high/FAK^low; IV, MACC1^high/FAK^high.