Table 1.

Genetic variants associated with HF pharmacotherapy response

GENE	VARIANT	rsID	BENEFICIAL ALLELE	REFERENCES
BETA BLOCKERS
ACE	Ins/Del	rs1799752	Del	[42, 69]
ADRA1D	T1848A	rs2236554	A	[27]
	A1905G	rs709024	G	[27]
ADRA2C	Ins/Del	rs61767072	Ins	[36]
			Del	[31]
ADRB1	Ser49Gly	rs1801252	Gly	[11, 13, 70-72]
	Arg389Gly	rs1801253	Arg	[2, 10, 11, 13, 14, 17, 25, 31, 35, 37, 71-73]
			Gly	[37]
ADRB2	Gln27Glu	rs1042714	Glu	[23-25, 37]
	Thr164Ile	rs1800888	Thr	[74]
EDN1	G/A (IVS)-4	rs2071942	G	[75]
	Lys198Asn	rs5370	Lys	[75]
GRK5	Gln41Leu	rs17098707	Gln	[33, 34]
NET	T-182C	rs2242446	T	[27]
ACE INHIBITORS
ACE	Ins/Del	rs1799752	Ins	[39-42, 45]
AGTR1	A1166C	rs5186	A	[45]
CYP11B2	T-344C	rs1799998	C	[43]
ALDOSTERONE ANTAGONISTS
ACE	Ins/Del	rs1799752	Ins	[76]
ANGIOTENSIN RECEPTOR BLOCKERS
AGTR1	A1166C	rs5186	C	[77]
HYDRALAZINE/ISOSORBIDE DINITRATE
CYP11B2	T-344C	rs1799998	C	[78]
NOS3	Glu298Asp	rs1799983	Glu	[79]
*LOOP DIURETICS
ACE	Ins/Del	rs1799752	Del	[52]
ADD1	Gly460Trp	rs4961	Trp	[52]
ANP	Val32Met	rs5063	Val	[52]
	Ter152Arg	rs5065	Arg	[52]
CYP2C9	CYP2C9*1/*2/*3	n/a	*3	[46]
GNB3	C825T	rs5443	C	[52]
SCNN1B	Most frequent haplotype vs. others	n/a	Most frequent haplotype	[50]
SCNN1G	C4G	rs5723	C	[50]
SLC12A3	Gly264Ala	rs1529927	Ala	[50]

^*Data from healthy volunteers

ACE = angiotensin converting enzyme, ADD1 = alpha adducin 1, ADRA1D = alpha-1d adrenergic receptor, ADRA2C = alpha-2c adrenergic receptor, ADRB1 = beta-1 adrenergic receptor, ADRB2 = beta-2 adrenergic receptor, AGTR1 = angiotensin II receptor type 1, Arg = arginine, ANP = atrial natriuretic peptide precursor, Asn = asparagine, CYP11B2 = cytochrome P450 family 11 subfamily B polypeptide 2, CYP2C9 = cytochrome P450 family 2 subfamily C polypeptide 9, Del = deletion, EDN1 = endothelin-1, Gln = glutamine, Glu = glutamic acid, Gly = glycine, GNB3 = guanine nucleotide binding protein beta polypeptide 3, GRK5 = G-protein coupled receptor kinase 5, Ile = isoleucine, Ins = insertion, IVS = intervening sequence, Leu = leucine, Lys = lysine, Met = methionine, NET = norepinephrine transporter, NOS3 = nitric oxide synthase 3, SCNN1B = sodium channel nonvoltage-gated 1 beta, SCNN1G = sodium channel nonvoltage-gated 1 gamma, Ser = serine, SLC12A3 = solute carrier family 12 member 3, Ter = termination, Thr = threonine, Trp = tryptophan, Val = valine