Skip to main content
. Author manuscript; available in PMC: 2014 Dec 9.
Published in final edited form as: Cancer Cell. 2013 Dec 9;24(6):751–765. doi: 10.1016/j.ccr.2013.10.013

Figure 6. Hysterectomy, salpingectomy, and oophorectomy experiments to assess the origins of HGSCs.

Figure 6

(A–E) Representative gross anatomy of tumor lesions found in mice undergoing hysterectomy. (A) Impact of hysterectomy on the development of bilateral ovarian HGSC tumors (OvT) originating in the fallopian tube (FT STIC) in a Brca2−/−;Tp53R270H/−;Pten−/− mouse. Black stars denote the removal of the uterus and the presence of the remaining fat deposits. FT STICs denote grossly normal appearing but histologically transformed fallopian tubes containing pre-invasive lesions. (B–D) Hysterectomy in a second Brca1+/−;Tp53−/−;Pten−/− mouse and the resultant HGSC metastasis to the ovary (encircled OvT) and peritoneum (encircled T). (D) The image depicts a higher magnification of the peritoneal HGSC metastasis (T). (E) Abdominal HGSC metastases (T) in a third Brca2−/−;Tp53R270H/−;Pten−/− mouse following hysterectomy. (F) Histopathological and immunohistochemical (CK8, PAX8, WT1, and TP53) analysis of ovarian (top subpanels) and peritoneal (bottom subpanels) HGSC metastases in murine models that underwent hysterectomy. Scale bars: 100 μm. See also Figure S4.