Table 2.

Examples of interactions between ion channels and integrin subunits in cells of TME.

cell type	ion channel type	integrin subunit type	evidence of ion channel expression
endothelial cells	Ca2+ channels (BKCa–increased cytosolic Ca2+)	β1, β3	[39,68]
endothelial cells	TRPV4	β1	[11]
vascular smooth muscle cells	L.type Cav1.2	α5β1	[39]
neutrophils	Cl–	β2	[45]
lymphocytes	Kv 1.3, KCa	β1	[16,50]