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A ‘conceptual’ scheme showing how growth factors (GF1, GF2, etc.) and steroid hormone (SH) signalling systems can feed through and compensate for each other in regulating expression/activity of the VGSC(s). In turn, VGSC activity enhances metastatic cell behaviour (MCB). Dotted, horizontal lines denote the interactive pathways, involving mostly the intracellular signalling cascades. (Online version in colour.)
