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. 2014 Mar 19;369(1638):20130109. doi: 10.1098/rstb.2013.0109

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© 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — Substrate overlaps between the transporters P-glycoprotein/MDR1, multi-drug-resistance-associated protein (MRP) and mitoxantrone-resistance protein (MXR). The substrate and inhibitor profiles for the transporters were obtained from micrographs that showed the steady-state accumulation of fluorescent drugs (60 min incubation at 37°C); adapted from [7]. BIS, bisantrene; CA, calcein; CA-AM, calcein-AM ester; COL, colchicine; DNR, daunorubicin; DOX, doxorubicin; EPI, epirubicin; LTC₄, leukotriene C4; LYS, LysoTracker; MTX, methotrexate; MX, mitoxantrone; NEM-GS, N-ethyl maleimide glutathione; PRA, prazosin; RHO, rhodamine 123; TXL, taxol; TOP, topotecan; VBL, vinblastine; VER, verapamil; VP-16, etoposide.