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Downregulation in the expression of K+ channels in the MDR phenotype. The expression index was determined using the Affymetrix GeneChip Mouse Genome 430 2.0 microarray and the GeneChip Expression Analysis system. (T Litman & EK Hoffmann 2009, unpublished data.)
| gene name | Wt EATC | MDR EATC |
|---|---|---|
| gene expression index | ||
| kcnn1 | 131 ± 2 | 108 ± 2 |
| kcnn4 | 1451 ± 12 | 1246 ± 14 |
| kcmf1 | 1450 ± 10 | 968 ± 15 |
