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. 2014 Jan 28;7:7. doi: 10.1186/1756-6606-7-7

Figure 5.

Figure 5

Increase of caspase-3 activity in cortical neurons of EPM2A-/- mice. A) Confocal images of cerebral cortex sections of EPM2A-/- mice with active-caspase-3 (red) and GAD67 (green). B) Magnification of the microphotography in panel A. These representative images revealed the activation of caspase-3 in non-GABAergic neurons. The GABAergic neurons contacts mainly with glutamatergic neurons and these neurons seem to activate the caspase-3 in laforin-deficient mice. C) Representative western blot of active-caspase-3 and active-caspase-9 quantification in the lysates of cerebral cortex in EPM2A-/- mice (1 month-old). D) Confocal images of cerebral cortex sections of EPM2A-/- mice with active-caspase-3 (green) and glutamatergic neuronal marker Glutamine synthetase Clone Gs-6 (red).