Skip to main content
. 2013 Dec 30;6(1):69–88. doi: 10.3390/v6010069

Figure 1.

Figure 1

Attachment of flaviviruses to C-type lectin receptors has different implications in flaviviruses infections. (A) In mammalian cells, DC-SIGN/L-SIGN and the mannose receptor (MR) act as attachment factors that bind virions and facilitate their entry by transferring them to the bona fide receptor(s) involved in endocytosis; (B) In mammalian cells, binding of flaviviruses to CLEC5A triggers DAP12 phosphorylation and downstream signaling pathways that lead to the release of pro-inflammatory cytokines and aggravation of the disease; (C) In mosquitoes, virus entry is facilitated by the binding of virus/mosGCTL-1 complexes to cellular mosPTP-1.