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Dual role of TAM receptors during flavivirus infection. During entry, TAM receptors capture virus-Gas6/ProS complexes and enhance virus internalization through still unknown mechanisms. In parallel, virus-Gas6/ProS complexes activate TAM receptors, which recruit interferon receptor (IFNAR) to induce SOCS1/3 expression, thereby inhibiting innate antiviral responses and facilitating flavivirus replication.
