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. 2014 Jan 14;6(1):243–263. doi: 10.3390/v6010243

Figure 3.

Figure 3

Schematic of TRIM5 and TRIMCyp genes. CypA cDNA retrotransposition into the TRIM5 gene of primates has occurred more than twice throughout evolution to produce in frame fusions of TRIM5 and CypA, with CypA replacing the B30.2 domain. (A) Native TRIM5 gene; (B) In owl monkeys, CypA insertion in intron 7 produces a TRIMCyp protein consisting of exons 2–7 with CypA replacing exon 8; (C) In macaques, CypA is downstream of TRIM5 and accompanied by a mutation leading to skipping of exons 7 and 8. The resultant protein is encoded by exons 2–6 followed by CypA. Untranslated exons shown in black, translated exons in blue, cyclophilin A (CypA) in red.