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Domain organization of SIVSMM-PBj gp41. The major gp41 structural regions are indicated: ectodomain, membrane-spanning domain (MSD) and cytoplasmic tail. The functional motifs within the ectodomain are depicted: the fusion peptide (FP) and the two heptad-repeats (HR1 and HR2). In the cytoplasmic domain, the two potential amphipathic α-helices are shown: lentiviral lytic peptides 2 and 1 (LLP-2 and LLP-1, respectively). Numbers correspond to the amino acid positions in the Env protein.
