The amino terminal region of the matrix (MA) domain of SIVSMM-PBj Gag. (Top) The domains of the SIV Gag polyprotein are depicted: matrix (MA, 135 amino acids), capsid (CA, 230 amino acids), nucleocapsid (NC, 52 amino acids), p6 (59 amino acids) and the spacer peptides SP1 (17 amino acids) and SP2 (14 amino acids). (Bottom) The amino acid sequence of the first 46 residues of the SIV MA is shown, indicating the α-helices 1 and 2, the β-turn, and the membrane-binding competent motifs: the myristic moiety that modifies the glycine at position 2 (arrow), the valine 7 and leucine 8 (underlined), and the polybasic region (amino acids 26–32, highlighted in red).