Table 1.
Demographic and genetic characteristics of the study population
| Colorectal Cancer |
Without Colorectal Cancer |
Total | |
|---|---|---|---|
| Gender | |||
| Male | 63 | 35 | 98 |
| Female | 62 | 60 | 122 |
| Race/Ethnicity | |||
| Caucasian | 102 | 83 | 185 |
| African American | 15 | 6 | 21 |
| Hispanic | 7 | 6 | 13 |
| Asian | 1 | 0 | 1 |
| Age | |||
| Median | 42 | 45 | 43 |
| Range | 22−84 | 18−84 | 18−84 |
| MMR mutation type* | |||
| MSH2 | 69 | 58 | 127 |
| MLHl | 57 | 37 | 94 |
| Mutation type | |||
| Missense † | 35 | 22 | 57 |
| Deletion/insertion/ truncating |
90 | 73 | 163 |
*
One patient with hoih MSH2 and MLHI mutated.
†
These missense mutations were confirmed to be pathogenic mutations by a Clinical Laboratory Improvement Act – certified laboratory or from the International Collaborative Group-HNPCC InSiGHT database or from the published literature (36, 37).