Table 6.
FISH probes that are commonly used for clinical diagnosis of solid tumors
| Probes | Cytogenetic anomaly | Associated disorder |
|---|---|---|
| CEP3,7,17; p16 |
Chromosome 3, 7, 17 aneuploidy; 9p21 |
Bladder carcinoma |
| HER-2/CEP17 |
17q11.2-q12 |
Breast cancer |
| TOP2A |
17q21-22 |
Breast cancer |
| TERC/CEP3 |
3q26.3 |
Cervical cancer |
| EWSR1 |
22q12 |
Ewing sarcoma |
| EGFR |
7p12 |
NSCLC |
| ALK |
2p23 |
NSCLC |
| ROS1 |
6p22 |
NSCLC |
| TMPRSS2/ETV1 |
21q22.3/7p21.1 |
Prostate cancer |
| TMPRSS2/ETV4 |
21q22.3/17q21.3 |
Prostate cancer |
| ERG | 21q22.2 | Prostate cancer |