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. Author manuscript; available in PMC: 2014 Feb 7.
Published in final edited form as: Open Toxinology J. 2010;2:24–42.

Table 2.

Main Diseases Associated to C. perfringens Major Toxins in Domestic Mammals

Sheep Goat Cattle Pigs Horses Other species
CPA Yellow lamb disease Not confirmed Not confirmed Not confirmed Not confirmed Not confirmed
CPB Lamb dysentery Struck Necrotizing enteritis Necrotizing enteritis Necrotizing enteritis (mainly piglets) Necrotizing enteritis (mainly foals) Necrotizing enteritis in several species
ETX Enterotoxemia Enterotoxemia Possible Enterotoxemia Not reported Not reported Not reported
ITX Enteritis Not reported Enterritis Not reported Not reported Enterotoxemia in rabbits
PFO Possible synergism with CPA in gangrene and ETX in enterotoxemia. No directly responsible for disease.
CPE Not reported Colitis Not reported Enteritis Enteritis Enteritis in dogs
CPB2 Not confirmed Not confirmed Not confirmed Neonatal diarrhea Possible enterocolitis Not confirmed