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. 2014 Jan 9;21(1):2. doi: 10.1186/1423-0127-21-2

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Copyright © 2014 Li et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Progesterone receptors mediate genomic and non-genomic actions in human endometrium. Uterine responsiveness to progesterone is dependent on nuclear PRA/B. Progesterone also acts through different membrane-bound PRs that mediate non-genomic activities. In addition to progesterone, nuclear PRA/B has been shown to be under estrogenic control in human and animal uteri. Although the non-genomic effects of membrane-bound PRs in the endometrium are unclear, several studies have suggested that the PRA/B-regulated genes are involved in the regulation of endometrial proliferation. PRA/B, progesterone receptor isoforms A and B.