Table 1.

Association results and cross-ethnic LD mapping at shared European and Mexican loci

HTG Locus	Pos.	Mexican Lead SNP	MA1	MAF2		Effect3 (CI95)	P-Value	European Lead SNP4		MAF		r2	r2
				MX	CEU				MA	MX	CEU	CEU5	MX6
APOA5	11q23	rs964184	G	0.30	0.12	1.77 (1.68-1.86)	5.5E-35	rs964184	G	0.30	0.12	1.0	1.0
GCKR	2p23	rs1260326	T	0.26	0.42	1.41 (1.32-1.5)	2.2E-13	rs1260326	T	0.26	0.42	1.0	1.0
LPL	8p21	rs12678919	G	0.05	0.12	0.53 (0.34-0.73)	2.7E-10	rs12678919	G	0.05	0.12	1.0	1.0
MLXIPL	7q11	rs2286276	T	0.12	0.26	0.72 (0.59-0.86)	2.2E-06	rs17145738	T	0.06	0.12	0.5	0.5
TIMD4	5q33	rs2036402	C	0.45	0.25	1.23 (1.14-1.32)	3.4E-06	rs1363232	A	0.10	0.30	0.1	0.1
CILP2	19p13	rs2228603	T	0.03	0.10	0.34 (0-0.84)	3.0E-05	rs10401969	C	0.05	0.10	0.7	0.2
ANGPTL3	1p31	rs10889337	A	0.45	0.35	0.83 (0.75-0.92)	3.3E-05	rs2131925	G	0.45	0.33	1.0	1.0
HDL-C Locus	Pos.	Mexican Lead SNP	MA1	MAF2		Effect3 (s.e)	P-Value	European Lead SNP4	MA	MAF		r2	r2
				MX	CEU					MX	CEU	CEU5	MX6
CETP	16q13	rs1532624	A	0.42	0.46	0.23 (0.02)	1.39E-24	rs3764261	A	0.40	0.35	0.5	0.7
LIPC	15q21	rs1077835	A	0.38	0.75	−0.17 (0.02)	2.1E-14	rs1532085	A	0.36	0.41	0.0	0.0
LOC55908	19p13	rs2278426	T	0.30	0.04	−0.14 (0.02)	3.44E-09	rs737337	C	0.32	0.07	0.5	0.9
		rs9282541	A	0.11	0.0	−0.37 (0.04)	6.4E-26	rs1883025	T	0.28	0.20	0.0	0.0
ABCA1	9q31	rs4149310	A	0.36	0.14	0.12 (0.02)	5.54E-08					0.0	0.0

¹MA, minor allele

²MAF in 200 Mexican control samples (MX) versus MAF in the CEU samples of HapMapIII.

³The effect size represents the odds-ratio (the 95% confidence interval) of each copy of the minor allele for the TG affection status and the proportion of 1 s.d change (standard error) for each copy of the minor allele for the continuous HDL-C levels.

⁴The lead SNP in Teslovich et al.⁷ European GWA meta-analysis.

⁵r² CEU, pairwise LD in r² between the lead Mexican SNP and lead European SNP in the CEU samples.

⁶r² MX, pairwise LD in r² between the lead Mexican SNP and lead European SNP in 200 Mexican control samples.