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Caki-2 cells were assayed for (A) nuclear chromatin condensation and (B) caspase-3 activity following treatment for 24 h with 15d-PGJ2 alone (20 μM), VP-16 alone (70 μM) and the combination of the two. Treatment with 15d-PGJ2 enhanced the VP-16-induced Caki-2 cell apoptosis via the activation of caspase-3. The results are expressed as the means ± SEM of three independent experiments. *P<0.05 vs. control cells. 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2; VP-16, etoposide.
