Table III.
mRNA expression levels of COL23A1 and COL24A1 in HNSCC samples (n=70).
| Patient and tumor characteristics (n=70) | COL23A1 expression levels | P-valueb | COL24A1 expression levels | P-valueb |
|---|---|---|---|---|
| Age (years) | ||||
| <70 (50) | 1.84±3.17 | 0.200 | 22.85±29.60 | 0.104 |
| ≥70 (20) | 0.95±1.77 | 39.28±62.86 | ||
| Gender | ||||
| Male (55) | 1.63±2.32 | 0.694 | 31.98±27.12 | 0.062 |
| Female (15) | 1.58±3.01 | 26.33±45.17 | ||
| Smoking status | ||||
| Non-smoker (22) | 1.78±4.11 | 0.939 | 20.67±23.39 | 0.257 |
| Smoker (48) | 1.50±2.11 | 30.69±47.91 | ||
| Alcohol exposure | ||||
| No (29) | 1.33±2.01 | 0.716 | 25.53±33.38 | 0.703 |
| Yes (41) | 1.77±3.33 | 28.97±47.25 | ||
| Tumor size | ||||
| T1–2 (21) | 0.71±0.92 | 0.238 | 39.66±60.84 | 0.045a |
| T3–4 (49) | 1.96±3.30 | 22.35±29.75 | ||
| Lymph-node status | ||||
| N0 (36) | 1.29±1.83 | 0.577 | 23.94±23.19 | 0.930 |
| N+ (34) | 1.90±3.65 | 31.36±55.31 | ||
| Tumor stage | ||||
| I, II, III (35) | 1.38±1.80 | 0.819 | 25.12±32.42 | 0.438 |
| IV (35) | 1.79±3.64 | 29.97±49.86 | ||
Data are expressed as means ± standard deviation.
a
P<0.05.
b
Mann-Whitney U test.
HNSCC, head and neck squamous cell carcinoma. COL21A1, collagen type XXI α1 mRNA; COL23A1, collagen type XXIII α1 mRNA.