Table 1. Patient demographic, biochemical and genetic characteristics.
| Patient demographic biochemical and genetic data | Mean (Range) |
| Age | 43,1 (18–70) |
| Sex (female/male) *n, [%] | 182* [45,7%]/216* [54,3%] |
| BMI (kg/m2) | 25,5 (16,6–45,5) |
| ALT_fact (times upper limit of normal, IU/l) | 1,9 (0,3–12,9) |
| AST_fact (times upper limit of normal, IU/l) | 1,34 (0,43–7,96) |
| GGT_fact (times upper limit of normal, IU/l) | 1,3 (0,2–16,1) |
| HOMA-index | 3,19 (0,1–22,6) |
| Ferritin (µg/l) | 174 (3,7–1846) |
| Triglyceride (mg/dl) | 104,4 (16–490) |
| AP (IU/l) | 70,4 (32–204) |
| TSH (µIU/ml) | 1,52 (0,01–12) |
| Fasting glucose (mg/dl) | 94 (60–201) |
| Cholesterol (mg/dl) | 174 (61–320) |
| Vitamin D baseline (ng/ml) | 18,7 (3–84,3) |
| Vitamin D TW 24 (ng/ml) | 19,5 (3,2–61,9) |
| IP10 baseline (pg/ml) | 254 (41,2–2000) |
| HCV-RNA (log IU/ml) | 5,6 (2,8–6,9) |
| HCV-subtype (1a/1b/1c) | 109 (33,3%)/210 (64,2%)/8 (2,4%) |
| IL28B-rs12979860 (CC/non_CC) | 117 (31,8%)/250 (68,1%) |
| CYP27B1-rs10877012 (AA/non_AA) | 39 (10,6%)/327 (89,3%) |
| CYP2R1- rs10741657 (AA/non_AA) | 51 (13,9%)/315 (86,1%) |
| DHCR7-rs12785878 (TT/non_TT) | 198 (52,8%)/177 (47,2%) |
| CYP24A1-rs6013897 (TT/non_TT) | 232 (61,8%)/143 (38,1%) |
| DHCR7-rs7944926 (GG/non_GG) | 204 (54,2%)/172 (45,7%) |
| DBP-rs2282679 (TT/non_TT) | 196 (52,2%)/179 (47,7%) |
| DBP-rs4588 (CC/non_CC) | 188 (50,1%)/187 (49,9%) |
| DBP-rs7041 (GG/non_GG) | 115 (30,6%)/260 (69,3%) |
| Fibrosis stage (0–2/3–4) *n, [%] | 321 [84,9%]/57 [15,1%] |
A VitD deficiency (<20 ng/ml) was observed in 251 (64,1%) out of 391patients. A liver fibrosis stage of 0–2 was observed in 321 (84,9%) out of 378 patients, while 57 (15%) out of 378 patients showed a liver fibrosis stage of 3–4.
Abbreviations: BMI: body-mass-index, ALT: alanine aminotransferase, AST: aspartate aminotransferase, gGT: gamma-glutamyl-transferase, HOMA: homeostatic model assessment of insulin resistance, AP: alkaline phosphatase, TSH: thyroid stimulating hormone, IP10: interferon-γ-inducible-protein-10, HCV: hepatitis C virus.
Missing data: Cholesterol levels were missing in 14 patients, Baseline Vitamin D levels were missing in 7 patients, Baseline IP10 levels were missing in 7 patients, Baseline viral load values were missing in 16 patients, Liver biopsy status was missing in 20 patients. HOMA-index values were missing in 74 patients, Triglyceride levels were missing in 15 patients, AP levels were missing in 4 patients, Ferritin levels were missing in 10 patients, Vitamin D levels on week 24 were missing in 69 patients, IP10 levels on week 1 were missing in 23 patients, IP10 levels on week 4 were missing in 42 patients, TSH values were missing in 6 patients, Genotype of the IL28B-gene was missing in 31 patients, Genotype of the CYP27B1-gene was missing in 32 patients, Genotype of the CYP2R1-gene was missing in 32 patients, Genotype of the DHCR7-genes was missing in 24 patients, Genotype of the CYP24A1-gene was missing in 24 patients, Genotype of the DBP-genes was missing in 24 patients.