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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2012 Jul 25;226(4):707–719. doi: 10.1007/s00213-012-2793-y

Figure 3. Post-reactivation memantine administration interfered with the reconsolidation of cocaine-CPP.

Figure 3

(a, b, c) Schematic representation of the experimental timelines for experiments 5, 6, and 7, respectively. (d, e, f) Cocaine-CPP expression for experiments 5, 6, and 7, respectively. Data are presented as Preference Score, as defined in Figure 1 legend. For (d) Saline group (n = 8); 10 mg/kg Memantine group (n = 10). Dashed line represents a PS less than 25% of test 1 PS, used to establish no-preference criteria. For (e) Saline group (n = 11); 10 mg/kg Memantine group (n = 13). For (f) Saline group (n = 12); Nonreactivated 10 mg/kg Memantine-treated Control group (n = 10); 10 mg/kg Memantine treatment group (n = 11). * Indicates significant difference from saline group (one-way ANOVAs, p < 0.01). Abbreviations: COC, cocaine; Sal, saline; C and Ccoc, 3 min confinement to the cocaine-paired compartment; Csal , 3 min confinement to the cocaine-unpaired compartment; T, Test.