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. 2014 Feb 7;9(2):e88501. doi: 10.1371/journal.pone.0088501

Figure 2. Septic pulmonary microvascular PMN sequestration is CD18-dependent.

Figure 2

CLP enhanced pulmonary microvascular PMN sequestration, as quantified by fluorescent labeling in fixed lung sections (histology, top graph) and in lungs of live animals (intravital videomicroscopy, IVVM, bottom graph). Septic pulmonary microvascular PMN sequestration was completely inhibited by pre-treatment with cyclophosphamide or anti-CD18 antibody, but not IgG control antibody (*, p<0.05 for CLP vs. respective sham group; #, p<0.05 for Untreated CLP vs. other CLP treatment groups; Two-Way ANOVA with Bonferroni post-hoc test; n = 4 [Sham] and 6 [CLP] per treatment).