Figure 3. Id1/Id3 knockout mice have decreased baseline capillary density and Id1 transgenic mice have decreased capillary rarefaction 7 days following IRI followed by increased rarefaction at 42 days following IRI compared with WT mice.

A) Immunofluorescence labeling of CD31 on outer medullary peritubular capillaries in normal kidneys (con) and at day 7 following IRI (IRD7) of indicated genotypes. B) Capillary rarefaction index (% area with no CD31 staining using 100 square grid) following IRI at indicated time points. *p<.001, **p = .04 compared with WT control kidneys (one way ANOVA with Tukey HSD test).