Table 5. Comparison of efficiencies of different methods for RD molecular diagnosis.

	N° Genes analyzed	Yield	Reference
APEX	1-16	15-44%	[44, 54]
Long-PCR	9	33%	[43]
Autozygome	16-100	42-52%	[48, 55]
Target Capture	105-179	36-56%	[11, 44-47, 56]
WES	All	44-83%*	[43, 48, 49, 57]
WGS	All	50%	[10]
RD-chip	100	47%	This study

*Higher efficiency percentages are obtained when few families or cases are analysed.