Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Oncogene. 2013 May 20;33(18):2307–2316. doi: 10.1038/onc.2013.187

Figure 7. TRPM7 silencing alters specific EGF signaling pathways.

Figure 7

Phosphorylation of A) EGFR (Tyr1173), B) Akt (Ser473), C) ERK1/2 (Thr202/Tyr204), and D) STAT3 (Tyr705) following EGF stimulation (50 ng/mL, 20 min) in MDA-MB-468 breast cancer cells transfected with nontargeting (NT) siRNA or TRPM7 OTP siRNA. Graphs show mean ± S.D. for three independent experiments. The effect of TRPM7 gene silencing on protein phosphorylation was assessed using two-way ANOVA with Bonferroni’s multiple comparisons post-tests. * P < 0.05.