2.
Molecules associated with ILK signalling
| Action | Molecule |
|---|---|
| Stimulates ILK activity | Integrins |
| PI3K (?) | |
| Activated by ILK | Affixin |
| MLC | |
| ERK | |
| Akt/PKB (?) | |
| Inhibits ILK | PTEN |
| ILKAP | |
| Inhibited by ILK | GSK-3 (?) |
| mTOR (?) | |
| Growth factors/Cytokines | ERα |
| Osteopontin | |
| VEGF(?) | |
| HER2/ErbB2(?) | |
| Tumour suppressors | DOC-2/hDab-2 |
| MDA-7 | |
| Other molecules affected by ILK | CREB |
| Cyclin D1 | |
| β-catenin | |
| AP-1 | |
| MMPs | |
AKT, protein kinase B (PKB); AP-1, activator protein-1; CREB, cAMP-response-element-binding protein; DOC-2/hDab-2, differentially-expressed in ovarian carcinoma-2/human disabled-2; ErbB2, epidermal growth factor receptor 2; ECM, extracellular matrix; ERα, estrogen receptor α; ERK, extracellular signal-regulated kinases; GSK3β, glycogen-synthase kinase-3β; ILKAP, integrin-linked kinase-associated serine/threonine phosphatase 2C; MDA-7, melanoma differentiation associated gene; MLC, myosin light chain; MMP, matrix metalloprotease; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol-3-kinase; PTEN phosphatase and tensin homolog VEGF, vascular endothelial growth factor. (?)-Denotes that action or pathway is undetermined.