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(A) EGFR dimerization upon ligand binding triggers auto-phosphorylation (P) and ubiquitination (Ub) of its cytoplasmic domain. This causes recruitment of effector proteins, like Grb2, Src and Cbl. (B) Intracellular route leading EGFR to down-regulation by lysosomal degradation. PM: plasma membrane, CCP: clathrin-coated pit, MVB: multivesicular body.
