2.
Haemodynamic parameters of sham, MI, MI+SAR and MI+CIL animals 8 weeks after surgery.
| SHAM (n = 19) | MI (n = 15) | MI+SAR (n = 18) | MI+CIL (n = 12) | |
|---|---|---|---|---|
| HR (beats/min.) | 310 ± 2.1 | 365 ± 5.5 * | 348 ± 3.2 # | 342 ± 4.1 # |
| MAP (mm Hg) | 113 ± 3.2 | 72 ± 1.2 * | 112 ± 4.1 # | 102 ± 3.3 # |
| LVSP (mm Hg) | 130 ± 4.6 | 88 ± 2.9 * | 119 ± 4.4 # | 108 ± 3.5 # |
| LVEDP (mm Hg) | 8.1 ± 0.42 | 19.8 ± 0.68 * | 10.2 ± 0.54 # | 11.1 ± 0.5 # |
| +dP/dt (mm Hg/sec) | 8186 ± 290 | 3306 ± 118 * | 6172 ± 216 # | 6280 ± 247 # |
| −dP/dt (mm Hg/sec) | 6738 ± 561 | 2740 ± 105 * | 4301 ± 220 # | 4529 ± 295 # |
Values are means ±S.E.M. MI, myocardial infarction; SAR, sarpogrelate; CIL, cilostazol; HR, heart rate; MAP, mean arterial pressure; LVSP, left ventricular systolic pressure; LVEDP, left ventricular end-diastolic pressure; +dP/dt, peak rate of pressure development; −dP/dt, peak rate of pressure decay. *P<0.05, significantly different from sham. #P<0.05, significantly different from MI.