Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Sp1/Sp3 ratio controls TβRII expression under IL-βtreatment. A: In the constitutive state, Sp1 ensures the basal transcription of TβRII. B: Under IL-1β exposure, NFκB accumulates by both activation (1) (after lκB phosphorylation) and transcription/translation (2) of p65 and then up-regulates Sp3 (3), which in turn competes with Sp1 (4) to down-regulate TβRII. (Alternatively, NFκB might interfere in this mechanism, since it is able to interact with Sp1 and Sp3).
