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. 2013 Oct 12;4(1):31–37. doi: 10.1007/s13346-013-0180-9

Fig. 1.

Fig. 1

Schematic representation of the paradigm shift in EVs. Since their discovery, EVs were initially considered to solely be cellular waste elimination systems (a). However, EVs have recently been found to contain both mRNA and miRNA. Additionally, EVs can be transferred between cells, and exosomal miRNAs were functional in recipient cells (b). Therefore, many researchers hope that EVs can be used as novel RNAi delivery systems for human therapy in the near future (c)