Fig. 3.

Ad-induced enhancement of monocyte-derived innate mediators on the infectious entry into epithelial cells. CAR and the integrin coreceptors are localized to the basolateral surface and tight intercellular junctions in confluent polarized epithelial cells, preventing species C Ad entry. Ad-infected monocytes produce IL-8 that induces redistribution of CAR and alpha v beta 3 integrin to the apical surface and allows virus infection from the apical airway lumen