Table 2.
Cost* and utility of pneumococcal disease in Chinese children ≤5 years of age
| Variable | Base-case estimate | Ranges for sensitivity analysis | Source |
|---|---|---|---|
| Cost |
|
|
|
| Bacteremia per episode |
2666.67 |
793.65–6349.21 |
Estimated |
| Meningitis per episode |
3587.3 |
476.19–7936.51 |
Estimated |
| Pneumonia per episode |
607.3 |
158.73–1587.3 |
Estimated |
| AOM per episode |
111.11 |
31.75–317.46 |
Estimated |
| Tympanostomy caused by AOM |
333.33 |
Base ± 25% |
Estimated |
| Hearing aids per unit |
634.92 |
300–1200 |
Estimated |
| Replacement interval (years) |
6 |
3–10 |
Estimated |
| Special education for disability per year |
2557.84 |
158.73–3174.6 |
Estimated |
| PCV-7 cost per dose |
136.51 |
102.38–170.63 |
Estimated |
| Cost of vaccine administration |
1.86 |
0–3.17 |
Estimated |
| Salary per day |
22.6 |
6.3–27.64 |
Estimated |
| Work-lost days for disease |
|
|
|
| Bacteremia |
8 |
6–10 |
Estimated |
| Meningitis |
9 |
6–12 |
Estimated |
| Pneumonia |
7 |
5–9 |
Estimated |
| AOM |
5 |
4–8 |
Estimated |
| Utility |
|
|
|
| Bacteremia |
0.9921 |
Base ± 25% |
[46-49] |
| Meningitis |
0.9768 |
Base ± 25% |
[46-49] |
| Pneumonia |
0.9921 |
Base ± 25% |
[46-49] |
| AOM |
0.995 |
Base ± 25% |
[46-49] |
| Tympanostomy caused by AOM |
0.82 |
Base ± 25% |
[46-49] |
| Long-term disability |
0.6 |
Base ± 25% |
[46-49] |
| Long-term deafness |
0.8 |
Base ± 25% |
[46-49] |
| Death | 0 | - | [46-49] |
*Costs are presented in US dollars (January 2012 exchange rate, US$ = CYN 6.30).