Table 2.
Measures of exploration of α 7- nAChRWT and KO mice as assessed in the BPM
Factor | Measure | Time Bin (min) |
Mean |
---|---|---|---|
Activity | Transitions | 0–20 | WT = 506.3 ± 9.1 |
KO = 486.4 ± 9.3 | |||
20–40 | WT = 366.9 ± 7.5 | ||
KO = 374.1 ± 10 | |||
40–60 | WT = 307.3 ± 8.1 | ||
KO = 277,5 ± 6.5 | |||
Center entries | 0–20 | WT = 59.17 ± 1.7 | |
KO = 55.57 ± 1.6 | |||
20–40 | WT = 38.83 ± 1.2 | ||
KO = 44.14 ± 1.6 | |||
40–60 | WT = 32.75 ± 1.4 | ||
KO = 34.00 ± 1.2 | |||
Specific exploration | Total holepoking | 0–20 | WT = 65.33 ± 1.2 |
KO = 65.86 ± 1.8 | |||
20–40 | WT = 67.00 ± 1.7 | ||
KO = 69.50 ± 1.7 | |||
40–60 | WT = 74.42 ± 2.7 | ||
KO = 59.93 ± 1.6 | |||
Varied holekeeping | 0–20 | WT = 7.8 ± 0.6 | |
KO = 11.8 ± 0.9* | |||
20–40 | WT = 9.4 ± 0.8 | ||
KO = 11.1 ± 1.1 | |||
40–60 | WT = 11.1 ± 1.1 | ||
KO = 9.1 ± 0.8 | |||
Rearing | 0–20 | WT = 87.92 ± 2.9 | |
KO = 84.42 ± 1.7 | |||
20–40 | WT = 97.75 ± 3.8 | ||
KO = 81.50 ± 2.1 | |||
40–60 | WT = 79.17 ± 3.0 | ||
KO = 71.07 ± 2.1 | |||
Locomotor patterns | Temporal CV | 0–20 | WT = 1.166 ± 0.012 |
KO = 1.245 ± 0.023 | |||
20–40 | WT = 1.377 ± 0.017 | ||
KO = 1.372 ± 0.024 | |||
40–60 | WT = 1.496 ± 0.035 | ||
KO = 1.687 ± 0.044 | |||
Spatial CV | 0–20 | WT =1.024 ± 0.007 | |
KO = 1.017 ± 0.007 | |||
20–40 | WT = 1.106 ± 0.010 | ||
KO = 1.087 ± 0.008 | |||
40–60 | WT = 1.094 ± 0.010 | ||
KO = 1.089 ± 0.011 |
P < 0.05 when compared to WT mice.