Table 1.
Parameter values.
| Name | Value | Sensitivity Range | Reference |
|---|---|---|---|
| TB Dynamics | |||
| TB Prevalence among suspects with HIV and CD4+ <100 cells/μL | 0.38 | 0.12–0.5 | Study data |
| Probability of death in those with TB and given TB treatment | 0.2 | 0.10–0.30 | 16 |
| Probability of dying from TB treatment toxicities | 5×10−5 | 8.5×10−6−1×10−2 | 26 |
| Characteristics of TB Diagnosis | |||
| Probability of empiric treatment among smear-negative TB cases | 0.53 | 0–0.75 | 27 |
| Probability of empiric treatment among patients without TB | 0.21 | 0–0.5 | 28 |
| LAM Sensitivity | 0.66 | 0.3–1 | Study data,13 |
| LAM Specificity | 0.95 | 0.7–1 | Study data,13 |
| Standard TB Diagnostics Sensitivity | 0.345 | 0.2–0.5 | 29 |
| Standard TB Diagnostics Specificity | 0.998 | 0.848–1 | 29 |
| Disability Weights | |||
| HIV+, on ART | 0.167 | 0.142–0.192 | 30 |
| TB | 0.264 | 0.224–0.304 | 30 |
| HIV+, not on ART | 0.505 | 0.429–0.581 | 30 |
| TB treatment | 0.10 | 0.085–0.115 | 30 |
| Life Expectancy (years) | |||
| HIV on ART (WHO Clinical Stage IV) | 5 | 1.5–10 | 22,31–34 |
| HIV acutely ill with TB | 0.0833 | 0.071–0.25 | Assumption |
| Unit Cost (2010 USD) | |||
| TB Treatment, South Africa | $850 | $500–$2000 | 17 |
| TB Treatment, Uganda | $178 | $100–$500 | 35 |
| LAM | $3.50 | $1.00–$30 | 29 |
| Standard TB Diagnostics | $1.58 | $1.34–$1.82 | 8 |
| Discount rate | 0.03 | 0–0.07 | 18 |