Table 2.

Ex vivo biodistribution of ^99mTc-labeled cAbBcII10 and cAbVCAM1-5 nanobodies 3h post-injection in C57Bl/6J and ApoE^−/− mice. Results are expressed as mean ± s.e.m.

	99mTc-cAbBcII10		99mTc-cAbVCAM1-5
	C57Bl6/J	ApoE−/−	C57Bl6/J	ApoE−/−
	Blood	0.4±0.0	0.4±0.0	0.5±0.1	0.6±0.1
Heart	0.1±0.0	0.2±0.0	0.2±0.0*	0.3±0.1*
Lung	0.8±0.2	1.0±0.1	1.7±0.2*	2.3±0.3*
Liver	1.0±0.1	0.6±0.0†	1.4±0.2	1.8±0.3*
SM	0.1±0.0	0.1±0.0	0.1±0.0	0.1±0.0
SG	0.3±0.0	0.2±0.0	0.5±0.0*	0.5±0.1*
Thyroid	0.5±0.1	0.4±0.1	0.7±0.1	0.7±0.1
Stomach	0.4±0.0	0.4±0.1	0.5±0.0*	0.6±0.1*
Bile	0.5±0.1	0.4±0.1	0.3±0.0	0.7±0.2
Kidney	350±16	267±14†	287±43	222±12
Spleen	0.3±0.0	0.4±0.0	7.4±0.2*	9.2±1.0*
Thymus	0.1±0.0	0.2±0.0	1.5±0.1*	1.7±0.1*
BM	0.4±0.0	1.0±0.7	7.9±2.0*	10.7±2.9*

^*P<0.05 vs strain-matched cAbBcII10.

^†P<0.05 vs C57Bl6/J.

SM, skeletal muscle; SG, salivary glands; BM, bone marrow.