Table 3.
Unadjusted and Risk-Adjusted Change in Blood Pressure (BP) and Goal Attainment Rates by Initial Antihypertensive Treatment Strategy
| Outcomes | FDC* | FEC* | Mono* | p values† | ||
|---|---|---|---|---|---|---|
| (n=795) | (n=712) | (n=7,169) | FDC vs. FEC | FDC vs. Mono | FEC vs. Mono | |
| Systolic, mm Hg | ||||||
| BP at index, mean (SD) | 153.8 (16.5) | 147.8 (16.4) | 148.2 (14.7) | <0.001 | <0.001 | 0.47 |
| BP at follow-up, mean (SD) | 132.3 (16.1) | 137.5 (18.6) | 134.9 (16.1) | <0.001 | <0.001 | <0.001 |
| Unadjusted change, mean (SD) | −21.5 (20.5) | −10.3 (20.7) | −13.3 (17.9) | <0.001 | <0.001 | <0.001 |
| Risk-adjusted change, mean (SD) | −17.3 (11.6) | −12.0 (11.5) | −13.6 (10.2) | <0.001 | <0.001 | 0.04 |
| Diastolic, mm Hg | ||||||
| BP at index, mean (SD) | 94.3 (11.1) | 85.9 (12.2) | 90.4 (10.6) | <0.001 | <0.001 | <0.001 |
| BP at follow-up, mean (SD) | 82.0 (10.6) | 79.8 (11.7) | 82.8 (10.5) | <0.001 | 0.06 | <0.001 |
| Unadjusted change, mean (SD) | −12.3 (12.3) | −6.1 (12.5) | −7.6 (11.4) | <0.001 | <0.001 | 0.003 |
| Risk-adjusted change, mean (SD) | −10.1 (6.8) | −6.0 (7.5) | −7.9 (6.6) | <0.001 | <0.001 | 0.34 |
| Goal attainment | ||||||
| Unadjusted at goal, n (%) | 440 (55.4) | 226 (37.4) | 3,267 (45.6) | <0.001 | <0.001 | <0.001 |
| Risk-adjusted at goal, n (%) | 455 (57.2) | 303 (42.5) | 3,216 (44.9) | <0.001 | <0.001 | 0.69 |
*
Abbrev: FDC, fixed-dose combinations; FEC, free-equivalent combinations; Mono, monotherapy.
†
Unadjusted p values were from analysis of variance (ANOVA) or logistic regression while risk-adjusted p values were from analysis of covariance (ANCOVA) or logistic regression.