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. Author manuscript; available in PMC: 2014 Nov 21.
Published in final edited form as: Cell. 2013 Nov 21;155(5):1154–1165. doi: 10.1016/j.cell.2013.10.042

Figure 3.

Figure 3

Inhibition of COX-2 eliminates deficits in long-term potentiation (LTP) by repeated Δ9-THC exposure. A1. Representative fEPSPs recorded at hippocampal CA3-CA1 synapses from WT animals repeatedly injected with vehicle, Δ9-THC (10 mg/kg), NS398 (10 mg/kg), or Δ9-THC+NS398 once daily for 7 consecutive days. LTP was measured 24 hr after cessation of the last injection. A2. Time courses of changes in fEPSP slope under different treatment. A3. Mean values of the potentiation of fEPSPs averaged from 56 to 60 min following TBS (n=6 to 8 slices/5~6 animals). B1. Representative fEPSPs recorded from COX-2 knockout (KO) mice injected with vehicle, or Δ9-THC (10 mg/kg) once daily for 7 consecutive days. B2. Time courses of changes in fEPSP slope induced by Δ9-THC. B3. Mean values of the potentiation of fEPSPs averaged from 56 to 60 min following TBS (n=8~12 slices/6~8 animals). Error bars represent ±SEM, **P<0.01 compared with vehicle controls; ##P<0.01 compared with Δ9-THC (ANOVA with Bonferronni post-hoc test). Scale bars in A1 and B1: 0.3 mV/10 msec. (See also Figures S3, S4.)