Fig. 2. A dichotomy exists in Meis1, c-jun, and relB expression (which are known to be c-jun-dependent) vs. DAPK1, (the dually-responsive c-jun/NF κB-dependent gene) in patient groups with normal karyotype Flt3ITD or MLL translocation.
A). Expression levels of DAPK1, is significantly different in NK Flt3 ITD or MLL translocation AML's when compared with cases without Flt3ITD or nonrandom cytogenetic abnormalities. B) In normal karyotype Flt3ITD and the tMLL AML group the expression ratios of DAPK1 to c-jun were statistically less compared with other cytogenetic/genotype categories, but there was no difference in the ratios of Meis1 to jun.