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NN1731/rFVIIa-AT complex formation during in vivo elimination of NN1731 and rFVIIa. NN1731 or rFVIIa (0·27 mg/kg) was administered i.v. to dogs, and plasma was sampled at various time points as indicated. Plasma was subjected to non-reduced sodium dodecyl sulphate polyacrylamide gel electrophoresis and FVIIa Western Blot analysis. Arrows indicate free NN1731/rFVIIa and complexes with AT with molecular masses of c. 50 and 100 kDa, respectively.
