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. Author manuscript; available in PMC: 2014 Feb 9.
Published in final edited form as: Br J Haematol. 2010 Nov 18;152(1):99–107. doi: 10.1111/j.1365-2141.2010.08432.x

Fig 4.

Fig 4

Time courses of FVIIa clot activity, FVIIa antigen and FVIIa-AT antigen concentrations in canine plasma spiked with NN1731 or rFVIIa in the absence and presence of heparin. Canine plasma stabilized with TAP and hirudin was spiked with 3 µg/ml NN1731 (lower panels) or 3 µg/ml rFVIIa (upper panels) at room temperature and incubated for various times in the absence (left panel) and presence of 2 u/ml heparin (right panels). FVIIa antigen concentration (closed circles), FVIIa clot activity (open circles) and FVIIa-AT antigen concentration (open squares) were measured.