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. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Aliment Pharmacol Ther. 2013 Nov 17;39(2):163–175. doi: 10.1111/apt.12555

Scatter plot, mean values and 95% confidence intervals for the 6TGN and 6MMPR concentrations in individual subjects by TPMT activity in the individualized dosing arm ( ) and in the weight-based arm (Δ) (per protocol analysis). A: 6TGN concentrations in normal metabolizers. B: 6MMPR concentrations in normal metabolizers. C: 6TGN concentrations in intermediate metabolizes. D: 6MMPR concentrations in intermediate metabolizes.

Inline graphic — Scatter plot, mean values and 95% confidence intervals for the 6TGN and 6MMPR concentrations in individual subjects by TPMT activity in the individualized dosing arm ( ) and in the weight-based arm (Δ) (per protocol analysis). A: 6TGN concentrations in normal metabolizers. B: 6MMPR concentrations in normal metabolizers. C: 6TGN concentrations in intermediate metabolizes. D: 6MMPR concentrations in intermediate metabolizes.