TABLE 1.
Patient Characteristics
Weight-based dose (n=25) | Individualized dose (n=25) | P | |
---|---|---|---|
Male | 10 (40%) | 12 (48%) | 0.78 |
Mean age (years) | 36.5±16.1 | 34.1±13.1 | 0.57 |
Mean weight (kg) | 70.1±20.5 | 73.2±19.8 | 0.59 |
White | 24 (96%) | 23 (92%) | 1.0 |
Adults/children | 22/3 | 23/2 | 1.0 |
Disease duration (months) | 70±114 | 114±127 | 0.20 |
Disease location | 0.68 | ||
Ileal | 9 (36%) | 11 (44%) | |
Colonic | 4 (16%) | 2 (8%) | |
Ileocolic | 12 (48%) | 12 (48%) | |
Steroid status | 0.49 | ||
Steroid-dependent | 12 (48%) | 12 (48%) | |
Steroid-refractory | 9 (36%) | 6 (24%) | |
Steroid-naive | 4 (16%) | 7 (28%) | |
Baseline TPMT (EU/mL RBC) | 28.9±7.6 | 28.6±9.2 | 0.90 |
High/Intermediate TPMT | 21/4 | 19/6 | 0.73 |
Current smoking | 2 (8%) | 3 (12%) | 1.0 |