Fig. 3.

Organ weights and regression analysis of DNAm vs. spleen mass and percent visceral fat. a Thymus and adrenal glands were weighed for corticosterone-treated (gray and black bars for 50 and 100 μg/ml, respectively) and vehicle-treated (white bars) mice. The absence of data for thymic mass of corticosterone-treated mice reflects a complete atrophy of the organ after 4 week of treatment with corticosterone. Asterisks indicate differences that are statistically significant (P<0.05). A strong correlation was observed between week-4 DNAm of Fkbp5 intron 1, CpG position 1 vs. spleen mass (b), and DNAm vs. percentage of visceral tat (c). Similar results were observed for CpG position 2 vs. spleen mass (d) and percentage of visceral fat (e). All of the organ weights are expressed as weight per gram total body weight of the mice