Figure 7.3.

Dll and dac CRMs. (A,B) Schematic of the Dll (A) and dac (B) genomic regions showing the positions of identified CRMs (colored boxes) and transcription units (large arrows). The expression patterns driven by individual CRMs is indicated and compared to the intact genes. All CRMs are mentioned in the text except for DllMX, DllWM, dac3EE, and dac5EE, which are not active during leg development, or DllBR, which is active very late in leg development (Galindo et al., 2011; Pappu et al., 2005). A Dll rescue transgene (“312 rescue”) and a small Dll deficiency (Dll^R28) both result in a nearly complete PD axis, with defects primarily in the tarsal segments. dac⁷, which removes dacRE, is a deficiency that eliminates both dac expression and the medial Dac domain in the leg.